Cooley anemia

Requires blood transfusions

Blood bags connected to arms and chest with red tubing.

Risk of secondary hemochromatosis

Darkened, cracked skin and black-red glowing veins show iron overload.

Marrow expansion → “crew cut” skull

Skull has spiked, ridged bone structures mimicking crew cut x-ray appearance.

Skeletal deformities

Hunched posture, enlarged head and ribs represent chronic bone changes.

Extramedullary hematopoiesis → hepatosplenomegaly

Distended, glowing abdomen on the left side (spleen/liver).

Target cells & anisopoikilocytosis

Floating red droplets: one with bullseye pattern (target cell), others irregular.

Parvovirus B19 → aplastic crisis

Shadowy bat figure behind vampire = parvovirus threat.

HbF is protective

Vampire holds glowing talisman around neck with fetal symbol.

Pigmented gallstones (chronic hemolysis)

Black bile drips from mouth; pouch with black stones.

Delayed onset after birth

Youthful appearance with cursed transformation = symptoms begin as HbF declines (~6 months old).