Anemia of Chronic Disease

Chronic inflammation (↑ IL-6 → ↑ hepcidin)

Flaming brain cloud above the vampire labeled INFLAMMATION = IL-6–driven immune activity.

↑ Hepcidin → ↓ iron absorption & ↓ iron release from macrophages

The vampire’s mouth is sealed, and his hands clench floating red cells — symbolic of trapped iron, unable to escape stores.

↓ Iron, ↓ TIBC, ↑ Ferritin

Vampire wears a broken hourglass medallion (low iron + blocked time), with a rusted chain belt = stored iron (↑ ferritin) but useless.

Normocytic, but can become microcytic

Red cells floating around him vary in size — some shrinking midair, symbolizing possible microcytic shift.

Associated with: chronic infections, neoplasia, CKD, autoimmune diseases

Background has a grave marker, tumor-like stone, and shadowy tendrils resembling autoimmune claws.

Underlying cause is key to treatment

His chest core glows dimly behind the armor — treat the disease, not just the anemia.