Hereditary Spherocytosis

Defect in RBC membrane proteins (ankyrin, band 3, spectrin, protein 4.2)

Vampire’s hands clutch distorted red blood cells, each malformed and rounded — symbolizing loss of membrane stability.

Autosomal dominant inheritance

Vampire wears a double-headed crest medallion, representing the passing of the dominant curse.

Small, round RBCs without central pallor

The RBCs in his hand are spherical, glowing, and solid — no central clearing = classic spherocytes.

Premature removal by spleen (extravascular hemolysis)

Massive, engorged spleen bulges grotesquely from the upper abdomen — overworking itself filtering defective RBCs.

Splenomegaly

The bloated upper left organ dripping with blood is a direct visual of massive splenomegaly.

Pigmented gallstones

Pile of black stones near his feet or on a belt pouch = from chronic hemolysis.

Aplastic crisis (parvovirus B19)

Skull in hand has a mask-like cracked red glyph = parvovirus as a looming threat of marrow collapse.

Treatment: splenectomy

Vampire is armored but with a faint surgical scar or broken chain across the spleen area = removal as a cure.